Elaine M Sinclair and Daniel J . Drucker Therapeutic Potential Proglucagon - Derived Peptides : Mechanisms of Action and

نویسندگان

  • Elaine M Sinclair
  • Daniel J. Drucker
  • Xiaowen Liu
  • Sangita G. Murali
  • Jens J. Holst
  • Timothy J Kowalski
  • Shijun Yang
  • Yun Ning
  • Robert A Del Vecchio
  • Frederique Poulet
  • Maureen Laverty
  • Galya Vassileva
  • Aaron Corona
  • Li Liu
  • Hana Baker
  • Andrei Golovko
  • Susan J Abbondanzo
  • Weiwen Hu
  • Sara Baldassano
  • Antonella Amato
  • Francesco Cappello
  • Francesca Rappa
  • Jiaming Mao
  • Xiaomin Hu
  • Yao Xiao
  • Chao Yang
  • Yi Ding
  • Ning Hou
  • Jue Wang
  • Heping Cheng
چکیده

[PDF] [Full Text] [Abstract] 2008; 295 (6): R1794-R1802. Am J Physiol Regul Integr Comp Physiol Xiaowen Liu, Sangita G. Murali, Jens J. Holst and Denise M. Ney increased insulin-like growth factor-I responses in rats Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with [PDF] [Full Text] [Abstract] , May , 2009; 201 (2): 219-230. Journal of Endocrinology Hedrick and Timothy J Kowalski Shijun Yang, Yun Ning, Robert A Del Vecchio, Frederique Poulet, Maureen Laverty, Eric L Gustafson, Joseph A Hong Lan, Galya Vassileva, Aaron Corona, Li Liu, Hana Baker, Andrei Golovko, Susan J Abbondanzo, Weiwen Hu, homeostasis GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic [PDF] [Full Text] [Abstract] , February , 2012; 302 (3): G352-G358. Am J Physiol Gastrointest Liver Physiol Sara Baldassano, Guo-Du Wang, Flavia Mulè and Jackie D. Wood vitro Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in [PDF] [Full Text] [Abstract] , April , 2013; 217 (1): 11-20. J Endocrinol Sara Baldassano, Antonella Amato, Francesco Cappello, Francesca Rappa and Flavia Mulè Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet [PDF] [Full Text] [Abstract] , November , 2013; 62 (11): 3736-3746. Diabetes Jiaming Mao, Xiaomin Hu, Yao Xiao, Chao Yang, Yi Ding, Ning Hou, Jue Wang, Heping Cheng and Xiuqin Zhang -Catenin Signaling in Obese Mice β Overnutrition Stimulates Intestinal Epithelium Proliferation Through

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Proglucagon-derived peptides: mechanisms of action and therapeutic potential.

Glucagon is used for the treatment of hypoglycemia, and glucagon receptor antagonists are under development for the treatment of type 2 diabetes. Moreover, glucagon-like peptide (GLP)-1 and GLP-2 receptor agonists appear to be promising therapies for the treatment of type 2 diabetes and intestinal disorders, respectively. This review discusses the physiological, pharmacological, and therapeutic...

متن کامل

Divergent regulation of human and rat proglucagon gene promoters in vivo.

A single mammalian proglucagon gene is expressed in the brain, islets, and intestinal enteroendocrine cells, which gives rise to a unique profile of proglucagon-derived peptides (PGDPs) in each tissue. The biological importance of glucagon, glucagon-like peptide (GLP)-1, and GLP-2 has engendered considerable interest in the factors regulating the synthesis and secretion of the PGDPs in vivo. Al...

متن کامل

Prolonged gastrointestinal transit in a patient with a glucagon-like peptide (GLP)-1- and -2-producing neuroendocrine tumor.

Neuroendocrine tumors overexpressing the proglucagon- derived peptides have been associated with severe constipation. The relationship between two of the intestinal proglucagon-derived peptides, glucagon-like peptide (GLP)-1 and -2, and delayed gastrointestinal transit, was characterized in a patient with a neuroendocrine proglucagon-derived peptide tumor. A 60-yr-old female presented with intr...

متن کامل

Pigment epithelium-derived factor: clinical significance in estrogen-dependent tissues and its potential in cancer therapy

Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of non-inhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and anti-metastatic properties. Although the structural domains of the PEDF gene that mediate such diverse ef...

متن کامل

Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides

Glucagon and glucagon-like peptide-1 (GLP-1) are produced in pancreatic α-cells and enteroendocrine L-cells, respectively, in a tissue-specific manner from the same precursor, proglucagon, that is encoded by glucagon gene (Gcg), and play critical roles in glucose homeostasis. Here, we studied glucose homeostasis and β-cell function of Gcg-deficient mice that are homozygous for a Gcg-GFP knock-i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005